Graph showing 20% collagen loss by age 40

What is collagen?

Collagen is a fibrous protein that helps maintain your skin’s shape and structure. The skin needs collagen to resist signs of aging, such as fine lines, wrinkles, and sagging.3-5 By age 40, most of us have lost up to 20% of our natural collagen.2

Sculptra helps stimulate natural collagen production.6 The poly-L-lactic acid (PLLA-SCA) in Sculptra forms a framework that helps support and maintain the skin’s inner structure, which may lead to a more youthful-looking appearance.1,3-5

Renewing the skin with Sculptra

  • 66.5%
    Sculptra showed a 66.5%
    increase in Type 1 collagen
    
after 3 months.6
66.5%
Sculptra showed a 66.5%
increase in Type 1 collagen

after 3 months.6
Image of Sculptra injection under the skin

Sculptra works deep within the skin

PLLA-SCA works underneath the skin to help restore the skin’s inner structure.6,7
Drawing of collagen stimulation

Stimulating natural collagen

As Sculptra PLLA-SCA microparticles are absorbed, they help stimulate and restore your own natural collagen production.1,6
Drawing of collagen restoration

Gradually restoring skin quality8,9

Collagen strands begin to rebuild gradually, helping to restore skin structure and reducing the appearance of wrinkles and folds.1

How Sculptra works

Go beneath the surface to see how Sculptra interacts with your skin.

Ready to take your next step?

Find a highly trained aesthetic injector near you to book a consultation, discuss your aesthetics goals, and get all your Sculptra questions answered in person.

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References
  1. Fitzgerald R, Bass LM, Goldberg DJ, Graivier MH, Lorenc ZP. Physiochemical characteristics of poly-L-lactic acid (PLLA). Aesthet Surg J. 2018;38(suppl 1):S13-S17.
  2. Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol. 1975;93(6):639-643.
  3. Shin J-W, Kwon S-H, Choi J-Y, et al. Molecular mechanisms of dermal aging and antiaging approaches. Int J Mol Sci. 2019;20(9):2126.
  4. Vleggaar D, Fitzgerald R. Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7(3):209-220.
  5. Oikarinen A. Aging of the skin connective tissue: how to measure the biochemical and mechanical properties of aging dermis. Photodermatol photoimmunol photomed. 1994;10(2):47-52.
  6. Goldberg D, Guana A, Volk A, Daro-Kaftan E. Single-arm study for the characterization of human tissue response to injectable poly-L-lactic acid. Dermatol Surg. 2013;39(6):915-922.
  7. Sculptra. Instructions for Use. Galderma Laboratories, L.P., 2023.
  8. Bohnert K, Dorizas A, Lorenc P, Sadick NS. Randomized, controlled, multicentered, double-blind investigation of injectable poly-L-lactic acid for improving skin quality. Dermatol Surg. 2019;45(5):718-724.
  9. Data on file. 43USSA1812EXT Clinical study report. Fort Worth, TX: Galderma Laboratories, L.P., 2022.

ISI-Global

Important Safety Information

Sculptra® (injectable poly-L-lactic acid [PLLA-SCA]) is indicated for correction of shallow to deep nasolabial fold contour deficiencies, fine lines and wrinkles in the cheek region, and other facial wrinkles.

Sculptra should not be used by people that are allergic to any ingredient of the product or have a history of keloid formation or hypertrophic scarring. Safety has not been established in patients who are pregnant, lactating, breastfeeding, or under 18 years of age.

Sculptra has unique injection requirements and should only be used by a trained healthcare practitioner. Contour deficiencies should not be overcorrected because they are expected to gradually improve after treatment.

Sculptra should not be injected into the blood vessels as it may cause vascular occlusion, infarction, or embolic phenomena. Use at the site of skin sores, cysts, pimples, rashes, hives, or infection should be postponed until healing is complete. Sculptra should not be injected into the red area (vermillion) of the lip or in the peri-orbital area.

The most common side effects after initial treatment include injection site swelling, tenderness, redness, pain, bruising, bleeding, itching, and lumps. Other side effects may include small lumps under the skin that are sometimes noticeable when pressing on the treated area. Larger lumps, some with delayed onset with or without inflammation or skin discoloration, have also been reported.

Sculptra is available only through a licensed practitioner. Complete Instructions for Use are available at www.SculptraUSA.com

Instructions for Use
Patient Safety Information

US-SCA-2300142

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