Injectable filler for smile lines and marionette lines

What is Sculptra?

SCULPTRA WORKS WITH YOUR BODY TO HELP REBUILD LOST COLLAGEN1,2,3
smile lines
marionette lines
chin wrinkles

Between the nose and mouth (nasolabial folds), commonly called "smile lines"

In the lines framing your mouth, also known as "marionette lines" or "laugh lines"

Appearance of wrinkles on the chin

Sculptra is an FDA-approved injectable that helps gradually replace lost collagen—the most common protein in the body that is used to form a framework to support cells and tissue—for results that can last up to two years.1,4,5,6*

*Clinical study ended at 25 months. The most common side effects after initial treatment include injection site swelling, tenderness, redness, pain, bruising, bleeding, itching and lumps. Other side effects may include small lumps under the skin that are sometimes noticeable when pressing on the treated area. Larger lumps, some with delayed onset with or without inflammation or skin discoloration, have also been reported.

Smile Lines

Between the nose and mouth (nasolabial folds), commonly called “smile lines”

Marionette Lines

In the lines framing your mouth, also known as “marionette lines” or “laugh lines”

Chin Wrinkles

Appearance of wrinkles on the chin

Why Sculptra?
Sculptra addresses an underlying cause of facial aging, not just the symptoms

Not All Anti-Aging Treatments Are the Same:

Collagen creams: Collagen creams do not fully penetrate to the dermis, so most topical treatments are effective as moisturizers that briefly improve the skin's appearance.7-9

Collagen Supplements: When ingested, the digestive system breaks down collagen proteins and their effectiveness remains inconclusive.10,11

Toxins: Toxins temporarily weaken muscles to minimize frown lines in the forehead. Results typically last a couple months.12,13

Fillers: Works immediately upon injection to fill in lines, wrinkles and folds.14

poly-L-lactic acid (PLLA) facial injection

Results appear gradually and can last up to two years.4†

†Treatment regimen is typically three injections over the course of three or four months. Individual results and treatments sessions may vary. Clinical trial ended at 96 weeks (2 years).

As a poly-L-lactic acid (PLLA) collagen stimulator, Sculptra helps restore the deep, underlying structure of the skin to diminish facial wrinkles.

Sculptra works with your body within the deep dermis to help revitalize collagen production and help restore your skin’s inner structure and volume.1,2,4

As the Sculptra PLLA microparticles are absorbed, they help stimulate collagen production.1,2,4

Rebuilt collagen strands begin gradually helping to restore facial volume and the look of fullness to wrinkles and folds.3

Sculptra may stimulate collagen growth which helps to restore facial volume and the look of fullness to wrinkles and folds over time.

Dermal filler

If you want to appear more youthful-looking — without appearing like you’ve had work done — then chances are Sculptra may be a good choice for you.

How does Sculptra work?
Slow and steady strength

Sculptra is made with biocompatible, biodegradable, synthetic material called poly-L-lactic acid, which is gradually and naturally absorbed by the body and helps to rebuild lost collagen through a series of treatments administered by a trained specialist.

The specialist injects treatment into the appropriate dermal plane where strands of collagen support your skin's structure. Over time, Sculptra helps the body reproduce lost collagen.1,2,4 The number of injection appointments and the number of injections per appointment vary from person to person, depending on how much collagen has been lost. On average, three injection appointments are needed over a period of a few months.

FIND A SPECIALIST
  • Sculptra Logo White

  • NOW FDA-APPROVED FOR

    CHEEK WRINKLES

  • The first and original PLLA collagen stimulator that, when injected in the cheek area, has been clinically shown to reduce cheek wrinkles, firm the skin and improve skin quality.1-4
    1. Sculptra. Instructions for Use. Galderma Laboratories, L.P. 2023.
    2. Data on file. 43USSA1812EXT clinical study report. Fort Worth, TX: Galderma Laboratories, L.P. 2022.
    3. Bohnert K. et al. Randomized, Controlled, Multicentered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid for Improving Skin Quality Dermatol Surg2019;45:718–724.
    4. Bergeret-Galley C. Comparison of Resorbable Soft Tissue Fillers. Aesthetic Surg J 2004; 24:33-46.

References:
  1. Stein P, Vitavska O, Kind P, Hoppe W, Wieczorek H, Süchurer NY. The biological basis for poly-L-lactic acid-induced augmentation. J Dermatol Sci. 2015;78(1):26–33.
  2. Goldberg D, Guana A, Volk A, Daro-Kaftan E. Single-arm study for the characterization of human tissue response to injectable poly-L-lactic acid. Dermatol Surg. 2013;39(6):915–922.
  3. Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. BR J Dermatol. 1975;93:639-643
  4. Sculptra injectable poly-L-lactic acid. Instructions for Use. Galderma Laboratories. 2021.
  5. Narins, Rhoda, Baumann, Lesie et. al. A Randomized Study of the Efficacy and Safety of Injectable Poly-L-lactic Acid Versus Human-Based Collagen implant in the treatment of nasolabial fold wrinkles
  6. Oikarinen Aging of the Skin Connective Tissue: How To Measure The Biolchemical and mechanical properties of aging dermis. 1994: 10: 47-52 Department of Dermatology, University of Oulu, Finland.
  7. Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308–319.
  8. Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018;27(5):729–738.
  9. Wrinkle creams: Your guide to younger looking skin. Mayo Clinic website. https://www.mayoclinic.org/diseases-conditions/wrinkles/in-depth/wrinkle-creams/art-20047463. Accessed January 17, 2020.
  10. Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018;19(10):3059. Published 2018 Oct 7.
  11. Can collagen supplements help tighten loose skin? Cleveland Clinic website. https://health.clevelandclinic.org/can-collagen-supplements-help-tighten-loose-skin/. Accessed January 17, 2020.
  12. Botox injections. Mayo Clinic website. https://www.mayoclinic.org/tests-procedures/botox/about/pac-20384658. Accessed January 17, 2020.
  13. Wrinkles. Mayo Clinic website. https://www.mayoclinic.org/diseases-conditions/wrinkles/diagnosis-treatment/drc-20354931. Accessed December 3, 2019.
  14. Injectable fillers guide. American Board of Cosmetic Surgery website. https://www.americanboardcosmeticsurgery.org/procedure-learning-center/non-surgical/injectable-fillers-guide/. Accessed January 17, 2020.
  15. Gogolewski S, Jovanovic M, Perren SM, Dillon JG, Hughes MK. Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). J Biomed Mater Res. 1993;27(9):1135–1148.

Patient Brochure

Click here for patient information about Sculptra® (PDF)

Important Safety Information

Indication: Sculptra® (injectable poly-L-lactic acid (PLLA-SCA)) is indicated for use in people with healthy immune systems for the correction of shallow to deep nasolabial fold contour deficiencies, fine lines and wrinkles in the cheek region, and other facial wrinkles.

Sculptra should not be used by people that are allergic to any ingredient of the product or have a history of keloid formation or hypertrophic scarring. Safety has not been established in patients who are pregnant, lactating, breastfeeding, or under 18 years of age.

Sculptra has unique injection requirements and should only be used by a trained healthcare practitioner. Contour deficiencies should not be overcorrected because they are expected to gradually improve after treatment.

Sculptra should not be injected into the blood vessels as it may cause vascular occlusion, infarction or embolic phenomena. Use at the site of skin sores, cysts, pimples, rashes, hives or infection should be postponed until healing is complete. Sculptra should not be injected into the red area (vermillion) of the lip or in the peri-orbital area.

The most common side effects after initial treatment include injection site swelling, tenderness, redness, pain, bruising, bleeding, itching and lumps. Other side effects may include small lumps under the skin that are sometimes noticeable when pressing on the treated area. Larger lumps, some with delayed onset with or without inflammation or skin discoloration, have also been reported.

Sculptra is available only through a licensed practitioner. View the complete Instructions for Use.

Important Safety Information | Instructions for Use

Indication: Sculptra® (injectable poly-L-lactic acid (PLLA-SCA)) is indicated for use in people with healthy immune systems for the correction of shallow to deep nasolabial fold contour deficiencies, fine lines and wrinkles in the cheek region, and other facial wrinkles.

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